Home
As expected, mammary tumors in males occurred far less fre-
quently than in females. Death in male rats was mostly due to
the development of severe hepatorenal insufficiencies, confirming
the first signs of toxicity observed in 90 day feeding trials with
NK603 maize (Spiroux de Vendômois et al., 2009). In females, kid-
ney ion leakages were evidenced at the biochemical levels at
month 15, when severe nephropathies were evidenced in dead
male animals afterwards, at the anatomopathological level. Early
signs of toxicity at month 3 in kidney and liver were also observed
for 19 edible GM crops containing pesticide residues (Séralini et al.,
2011). As a matter of fact, only elderly male rats are sensitive to
chronic progressive nephropathies (Hard and Khan, 2004). The dis-
turbed kidney parameters may have been induced by the reduction
of phenolic acids in our study, since caffeic and ferulic acids are
beneficial in the kidney as they prevent oxidative stress (Srinivasan
et al., 2005; U Rehman and Sultana, 2011). Accordingly, we previ-
ously demonstrated that plant extracts containing ferulic and caf-
feic acids were able to promote detoxification of embryonic kidney
cells after R contamination (Gasnier et al., 2011). It is thus possible
that NK603 consumption by reducing these compounds may well
provoke an early aging of kidney physiology in this study, like R
by oxidative stress.
[link to research.sustainablefoodtrust.org]
quently than in females. Death in male rats was mostly due to
the development of severe hepatorenal insufficiencies, confirming
the first signs of toxicity observed in 90 day feeding trials with
NK603 maize (Spiroux de Vendômois et al., 2009). In females, kid-
ney ion leakages were evidenced at the biochemical levels at
month 15, when severe nephropathies were evidenced in dead
male animals afterwards, at the anatomopathological level. Early
signs of toxicity at month 3 in kidney and liver were also observed
for 19 edible GM crops containing pesticide residues (Séralini et al.,
2011). As a matter of fact, only elderly male rats are sensitive to
chronic progressive nephropathies (Hard and Khan, 2004). The dis-
turbed kidney parameters may have been induced by the reduction
of phenolic acids in our study, since caffeic and ferulic acids are
beneficial in the kidney as they prevent oxidative stress (Srinivasan
et al., 2005; U Rehman and Sultana, 2011). Accordingly, we previ-
ously demonstrated that plant extracts containing ferulic and caf-
feic acids were able to promote detoxification of embryonic kidney
cells after R contamination (Gasnier et al., 2011). It is thus possible
that NK603 consumption by reducing these compounds may well
provoke an early aging of kidney physiology in this study, like R
by oxidative stress.
[link to research.sustainablefoodtrust.org]
